Cancer stem cells (CSCs) are considered the root of primary and acquired therapy resistances associated with disease progression and poor clinical outcomes in cancer patients. Therefore, an elucidation of the key molecular mechanisms regulating CSC activities could help with the development of novel biomarkers and therapeutic targets to predict or combat the most aggressive malignant tumors in patients.
The following aspects of the subject area will be highlighted in this Special Issue:
- signalling pathways;
- CSCs in treatment failure;
- CSC metabolism;
- circadian rhythms in CSCs;
- CSCs and microenvironmental factors;
- biological, biochemical, and pathological methods allowing CSC identification within malignant tumors;
- pediatric tumors and CSCs;
- epigenetic factors in CSC formation;
- glioblastoma stem cells;
- chemical agents against CSCs; t
- ranslational oncology
Dr. Mariela Vasileva-Slaveva will join the EXTRO-Lab team from November 1, 2019. Mariela has received an ESMO Fellowship-2019 for her project
Dr. Irma Kvitsaridze, Radiation Oncologist (Dept. of Therapeutic Radiology and Oncology) has started her cooperation with the EXTRO-Lab team. Irma will conduct her clinical research projects in cooperation with lab members.
August 1, 2019
PhD Student Bertram Aschenbrenner has been awarded with the Marietta Blau Grant. Marietta Blau Grant supports the PhD Student's research activities in foreign countries to improve an impact of their PhD thesis:
Bertram Aschenbrenner will work for 6 months on the project "Radiation-induced ferroptosis as a tool to combat metastatic breast cancer" at the National Insitute for Quantum and Radiological Science and Technology (QST) in Chiba (Japan). Bertram will perform his study in collaboration with Dr. Ryoichi Hirayama, and the effect of heavy ion radiotherapy (carbon ions) on breast cancer stem cells will be studied.
July 10-12, 2019
EXTRO-Lab has extended its international collaborations. Cancer researchers Prof. Dr. Rusudan Sujashvili and Dr. Mariam Abuladze (New Vision University, Tbilisi, Gergia) have visited the EXTRO-Lab. Both Georgian and Austrian partners will work on the problems of breast cancer treatment.
EXTRO-Lab members participated in the EACR-25 in Amsterdam:
Our PhD Students Giulia Negro and Bertram Aschenbrenner presented their recent data on the radioresistance of breast cancer cells. Their Poster presentations were presented at the Poster Session "Radiobiology, Radiation Oncology":
PO-115 Radiation resistance mechanisms of breast cancer cells
G. Negro, B. Aschenbrenner, S. Skvortsov, C. Jimenez, U. Ganswindt, I. Skvortsova
PO-120 Metastatic breast cancer: Underlying molecular mechanisms of radiation response
B. Aschenbrenner, G. Negro, S. Skvortsov, U. Ganswindt, S. Kranjc, M. Čemažar, I. Skvortsova.
We thank all colleagues contributed to the research projects, and we hope on further fruitful collaboration!
See photos from the EACR-25 here: Photos from EACR-25
EXTRO-Lab has new PhD Student Dragana Savic:
Our new colleague PhD Student Dragana Savic will work on the ÖNB project 17620 "Non-invasive exosome-based method to predict HNSCC recurrence after radiotherapy".
Laura Pezze is a guest researcher in Innsbruck:
Laura Pezze has received an EACR fellowship to perform a part of her research project at EXTRO-Lab. Laura is a PhD Student at CIBIO, Laboratory of Molecular Cancer Genetics, Trento, Italy
Life Science PhD Meeting in Innsbruck:
PhD Student Bertram Aschenbrenner has presented his recent data at the meeting. His research was supported by the FWF (Austrian Science Fund), Ingrid Shaker-Nesmann Foundation, and WTZ-ÖAD Austrian-Slovenian Project. EXTRO-Lab team specially thanks our Slovenian colleagues Dr. Simona Kranjc and Prof. Dr. Maja Cemazar for the performed in vivo experiments.
EACR Conference Series:
EACR Ambassador Ira Skvortsova is inviting you to attend the EACR Conferences.
Today is the last day to submit your abstract to the EACR-25 (30 June - 3 July 2018, Amsterdam, the Netherlands)
Visit the EACR Website and submit your abstract!
PhD Student Giulia Negro has been awarded a travel grant to attend a FEBS Conference "Emerging issues of breast cancer research: tumour heterogeneity, immunotherapy, and cellular metabolism (4-8 April 2018, Budapest, Hungary)
Owing to the financial support from the Austrian Science Fund (FWF Project P29457), Ingrid Shaker Nessmann Cancer Research Foundation, and OeAD (Sl 25/2018), Giulia has received interesting research data underlying the radiation resistance of metastatic breast cancer cells. These results will be presented at the conference in Budapest. Good luck, Giulia!
Financial Support from the Austrian National Bank (ÖNB)
Next project by Ira Skvortsova was granted by the ÖNB Foundation:
Non-invasive exosome-based method to predict HNSCC recurrence after radiotherapy
Merry Christmas and Happy New 2018 Year!
December 7, 2017
EXTRO-Lab team has participated in the competition to get a Nanolive 3D-Cell Explorer Microscope to realize a research project, and the results of this competition were announced on December 4, 2017
September 26-27, 2017: Invitation
Seminar and Lionheart Instrument Demonstration:
Dr. Fabian Kuck (BioTek) will be presenting the Lionheart FX Live-Cell Imager.
In this presentation we will talk about how quantitative image-based results for cell biology can be achieved through automated digital microscopy and image analysis techniques under both fixed and live cell conditions. Lionheart™ FX Automated Microscope is an inclusive microscopy system, optimized for live cell imaging with up to 100x air and oil immersion magnification, with brightfield, color brightfield, phase contrast and fluorescence channels. A unique environment control cover provides incubation to 40°C and effective containment for CO2/O2 control. The available humidity chamber and reagent injection port add a greater level of environment optimization for live cell imaging workflows. Lionheart FX and Gen5 together comprise Augmented Microscopy™ - the automation of image capture, processing, analysis and development of publication-ready images and data.
Please join us for the
When: Tuesday September 26, 2017 at 13:00
Where: TKFI, Labor 1 (Innrain 66)
Lionheart FX Live-Cell Imager Seminar:
When: Wednesday September 27, 2017 at 10:00
Where: TKFI Seminar room (Innrain 66A, G0)
September 2017: Giulia Negro has presented the recent data on breast cancer stem cells at the 12th Annual Meeting of the EORTC PathoBiology Group in Aviano (Italy), September 14-16, 2017.
We will report on the meeting and Giulia's presentation in the EXTRO-Lab Blog. Read us!
September 2017: Ira-Ida Skvortsova has been awarded by Immunotools
See here: https://www.extro-lab.at/blog/
June 2017: Bioscope Summer Course in June 2017, in Caparica (Lisbon, Portugal)
Giulia Negro and Bertram Aschenbrenner will participate in this course:
VII Hands-on Course in Sample Preparation Using Nanoparticles for
Module I - Theory
Synthesis and characterization of nanoparticles
Nanoparticle-based sample fractionation
Protein identification by Mass Spectrometry
Module II - Hands-on
Sample clean up
Nanoparticle synthesis characterization and applications:
Protein fractionation using gold-nanoparticles (serum samples)
Characterization of GNPs-protein complexes (UV-Vis, SDS-PAGE)
In-gel and In-solution protein digestion (GNPs-protein complexes)
Protein identification using MALDI-TOF/TOF MS
We are waiting for interesting reports!
Seminar and ELLA Instrument Demonstration (180 min.)
Dr. Michael V. Stein (European Business Manager Immunoassay Solutions Luminex & SimplePlex, Bio-Techne) will be presenting SimplePlex Assay.
Please join us for this presentation.
When: Tuesday May 16, 2017 at 10:00
Where: Tyrolean Cancer Research Institute (TKFI)